Wolfram syndrome model: temporal lobe
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE15293
TitleWolfram syndrome model: temporal lobe
DescriptionAnalysis of temporal lobes of C57B6 and 129S6 animals deficient for the Wfs1 protein. WFS1 gene mutations cause the Wolfram syndrome, an autosomal recessive disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 is expressed in the temporal lobe.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15293
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Geneset

Small molecules which mimic WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse WFS1 KO
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated in WFS1 KO
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated in WFS1 KO
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated in WFS1 KO
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated in Wolfram syndrome
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
...
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