BINOCh
Computational Tool
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General Information
DescriptionBinding inference from nucleosome occupancy changes
Homepagehttp://liulab.dfci.harvard.edu/BINOCh
Publications
BINOCh: binding inference from nucleosome occupancy changes
Clifford A. Meyer; Housheng H. He; Myles Brown; X. Shirley Liu
Summary: Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biologists to use such data to infer the identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation.
Availability: The BINOCh open source Python package is freely available at http://liulab.dfci.harvard.edu/BINOCh under the FreeBSD license.
Contact: cliff@jimmy.harvard.edu; xsliu@jimmy.harvard.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
DOI: https://doi.org/10.1093/bioinformatics/btr279
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