GOssTo
Computational Tool
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General Information
DescriptionA stand-alone application and a web tool for calculating semantic similarities on the Gene Ontology
Homepagehttp://www.paccanarolab.org/gossto
Publications
GOssTo: a stand-alone application and a web tool for calculating semantic similarities on the Gene Ontology
Horacio Caniza; Alfonso E. Romero; Samuel Heron; Haixuan Yang; Alessandra Devoto; Marco Frasca; Marco Mesiti; Giorgio Valentini; Alberto Paccanaro
Summary: We present GOssTo, the Gene Ontology semantic similarity Tool, a user-friendly software system for calculating semantic similarities between gene products according to the Gene Ontology. GOssTo is bundled with six semantic similarity measures, including both term- and graph-based measures, and has extension capabilities to allow the user to add new similarities. Importantly, for any measure, GOssTo can also calculate the Random Walk Contribution that has been shown to greatly improve the accuracy of similarity measures. GOssTo is very fast, easy to use, and it allows the calculation of similarities on a genomic scale in a few minutes on a regular desktop machine.
Contact : alberto@cs.rhul.ac.uk
Availability: GOssTo is available both as a stand-alone application running on GNU/Linux, Windows and MacOS from www.paccanarolab.org/gossto and as a web application from www.paccanarolab.org/gosstoweb . The stand-alone application features a simple and concise command line interface for easy integration into high-throughput data processing pipelines.
DOI: https://doi.org/10.1093/bioinformatics/btu144
Metrics:
8
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