General Information
| Description | Updating maSigPro bioconductor package for RNA-seq time series |
| Homepage | http://bioconductor.org |
Publications
Next maSigPro: updating maSigPro bioconductor package for RNA-seq time series
Motivation:
The widespread adoption of RNA-seq to quantitatively measure gene expression has increased the scope of sequencing experimental designs to include time-course experiments. maSigPro is an R package specifically suited for the analysis of time-course gene expression data, which was developed originally for microarrays and hence was limited in its application to count data.
Results:
We have updated maSigPro to support RNA-seq time series analysis by introducing generalized linear models in the algorithm to support the modeling of count data while maintaining the traditional functionalities of the package. We show a good performance of the maSigPro-GLM method in several simulated time-course scenarios and in a real experimental dataset.
Availability and implementation:
The package is freely available under the LGPL license from the Bioconductor Web site ( http://bioconductor.org ).
Contact:
mj.nueda@ua.es or aconesa@cipf.es
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