General Information
| Description | A software tool for top-down mass spectrometry-based proteoform identification and characterization |
| Homepage | http://proteomics.informatics.iupui.edu/software/toppic/ |
Publications
TopPIC: a software tool for top-down mass spectrometry-based proteoform identification and characterization
Summary:
Top-down mass spectrometry enables the observation of whole complex proteoforms in biological samples and provides crucial information complementary to bottom-up mass spectrometry. Because of the complexity of top-down mass spectra and proteoforms, it is a challenging problem to efficiently interpret top-down tandem mass spectra in high-throughput proteome-level proteomics studies. We present TopPIC, a tool that efficiently identifies and characterizes complex proteoforms with unknown primary structure alterations, such as amino acid mutations and post-translational modifications, by searching top-down tandem mass spectra against a protein database.
Availability and Implementation:
http://proteomics.informatics.iupui.edu/software/toppic/
Contact:
xwliu@iupui.edu
Supplementary information:
Supplementary data are available at Bioinformatics online.
Related Tools
Prophossi
Published July 2010
Automating expert validation of phosphopeptide–spectrum matches from tandem mass spectrometry
GlycanAnalysis Plug-in
Published February 2015
A database search tool for N-glycan structures using mass spectrometry
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.
