| Name | Description | Size |
|---|---|---|
| Adjacency_matrix_LM_space_42809x42809.gctx | Adjacency matrix of all significant CD signatures. Cosine similarity is used to compute the signature similarity. | 13.7GB |
| CD_signatures_LM_42809x978.gctx | CD signature matrix in the Landmark gene space. | 330.6MB |
| CD_signatures_full_42809x22268.gctx | CD signature matrix in the full space (22268 probes). | 7.1GB |
| CD_signatures_binary_42809.gmt | CD signatures (up/down gene sets) in the full space in gmt format. | 115.0MB |
| CD_signatures_binary_42809.json | CD signatures (up/down gene sets) in the full space in json format. | 169.5MB |
| CD_signature_metadata.csv | Metadata of the signatures indexed by the `sig_id`. | 4.8MB |
| Drugs_metadata.csv | Metadata of the drugs indexed by the `pert_id` | 7.4MB |
| Probes_L1000_metadata.csv | Metadata of the probes of the Landmark genes. | 16.3KB |
| Probes_full_metadata.csv | Metadata of the probes used in the full space. | 364.2KB |
| Plot | Cell line | Signatures |
|---|---|---|
| All cell lines | all | 16848 |
| BT20 (FWD) | BT20 | 571 |
| THP1 (tSNE) | THP1 | 229 |
| NPC (tSNE) | NPC | 973 |
| HT29 (tSNE) | HT29 | 2717 |
| A549 (FWD) | A549 | 4115 |
| A375 (FWD) | A375 | 3086 |
| A375 (tSNE) | A375 | 3086 |
| HCC515 (tSNE) | HCC515 | 2504 |
| MDAMB231 (FWD) | MDAMB231 | 545 |
| HEPG2 (tSNE) | HEPG2 | 1861 |
| HCC515 (FWD) | HCC515 | 2504 |
| MDAMB231 (tSNE) | MDAMB231 | 545 |
| NEU (tSNE) | NEU | 378 |
| SKB (tSNE) | SKB | 868 |
| A549 (tSNE) | A549 | 4115 |
| SKBR3 (FWD) | SKBR3 | 541 |
| HA1E (FWD) | HA1E | 3005 |
| MCF10A (tSNE) | MCF10A | 471 |
| ASC (FWD) | ASC | 777 |
| VCAP (FWD) | VCAP | 5856 |
| HT29 (FWD) | HT29 | 2717 |
| BT20 (tSNE) | BT20 | 571 |
| VCAP (tSNE) | VCAP | 5856 |
| MCF7 (FWD) | MCF7 | 6965 |
| THP1 (FWD) | THP1 | 229 |
| ASC (tSNE) | ASC | 777 |
| MCF10A (FWD) | MCF10A | 471 |
| NEU (FWD) | NEU | 378 |
| PC3 (tSNE) | PC3 | 5638 |
| HA1E (tSNE) | HA1E | 3005 |
| SKB (FWD) | SKB | 868 |
| NPC (FWD) | NPC | 973 |
| SKBR3 (tSNE) | SKBR3 | 541 |
| MCF7 (tSNE) | MCF7 | 6965 |
| HS578T (tSNE) | HS578T | 454 |
| PHH (tSNE) | PHH | 505 |
| PHH (FWD) | PHH | 505 |
| PC3 (FWD) | PC3 | 5638 |
| HS578T (FWD) | HS578T | 454 |
| HEPG2 (FWD) | HEPG2 | 1861 |