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| Title / Description | Dopaminergic neurotoxin MPTP-based Parkinson's disease risk model: brain regions |
| Accession | GDS4157 |
| Summary | Analysis of caudate-putamen and pre-frontal cortex from transgenics, over-expressing either risk-associated synaptic acetylcholinesterase (AChE)-S variant or the protective soluble AChE-R variant, exposed to environmental risk factor MPTP. Results provide insights into the molecular basis of PD. |
| Organism | Mus musculus |
| Platform | GPL8321 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | ACHE |
| Cell | Mouse prefrontal cortex |
| Perturbation | MPTP treatment + AChES overexpression (compared to WT control) |
| Disease | PD |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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