LILY_PD gene signatures (74)

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Title Organism Platform Optional Metadata
1 Early Parkinson's disease: peripheral blood Homo sapiens Homo sapiens
Cell Blood
Perturbation Early stage of PD
Disease PD
2 H9 hESC-derived neural stem cells harboring ... Homo sapiens Homo sapiens
Gene LRRK2
Cell Neural stem cell (NSC)
Perturbation LRRK2 G2019S mutation
Disease PD
3 H9 hESC-derived neural stem cells harboring ... Homo sapiens Homo sapiens
Gene LRRK2
Cell Neural stem cell (NSC)
Perturbation LRRK2 G2019S mutation ...
Disease PD
4 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell Fibroblast
Perturbation LRRK2 G2019S mutation ...
Disease PD
5 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell Fibroblast
Perturbation LRRK2 G2019S mutation ...
Disease PD
6 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell iPSC
Perturbation LRRK2 G2019S mutation ...
Disease PD
7 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell iPSC
Perturbation LRRK2 G2019S mutation ...
Disease PD
8 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell WT ESC, mutant iPSC
Perturbation LRRK2 G2019S mutation ...
Disease PD
9 Fibroblast-derived induced pluripotent stem ... Homo sapiens Homo sapiens
Gene LRRK2
Cell WT ESC, mutant iPSC
Perturbation LRRK2 G2019S mutation ...
Disease PD
10 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Cell Mouse caudateputamen
Perturbation MPTP treatment
Disease PD
11 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Cell Mouse prefrontal cortex
Perturbation MPTP treatment
Disease PD
12 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
13 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse caudateputamen
Perturbation MPTP treatment + ...
Disease PD
14 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
15 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse caudate putamen
Perturbation AChER overexpression ...
Disease PD
16 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation AChER overexpression ...
Disease PD
17 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
18 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
19 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse caudate putamen
Perturbation AChES overexpression ...
Disease PD
20 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation AChES overexpression ...
Disease PD
21 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse caudate putamen
Perturbation MPTP treatment + ...
Disease PD
22 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
23 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse caudate putamen
Perturbation MPTP treatment + ...
Disease PD
24 Dopaminergic neurotoxin MPTP-based Parkinson's ... Mus musculus Mus musculus
Gene ACHE
Cell Mouse prefrontal cortex
Perturbation MPTP treatment + ...
Disease PD
25 Parkinson's disease induced pluripotent stem ... Homo sapiens Homo sapiens
Gene SNCA
Cell iPSC
Perturbation SNCA triplication
Disease PD
26 Dopaminergic transcription factors Ascl1, ... Mus musculus Mus musculus
Cell Mouse embryonic ...
Perturbation Reprogramming to iDA ...
Disease PD
27 Parkinson's disease: post-mortem medullary regions Homo sapiens Homo sapiens
Cell Dorsal motor nucleus ...
Perturbation Sporadic PD
Disease PD
28 Parkinson's disease: post-mortem medullary regions Homo sapiens Homo sapiens
Cell Inferior olivary ...
Perturbation Sporadic PD
Disease PD
29 Alpha-synuclein deficiency effect on striatum ... Mus musculus Mus musculus
Gene SNCA
Cell Cerebellum (6 month)
Perturbation SNCA knockout
Disease PD
30 Alpha-synuclein deficiency effect on striatum ... Mus musculus Mus musculus
Gene SNCA
Cell Striatum (6 month)
Perturbation SNCA knockout
Disease PD
31 Alpha-synuclein deficiency effect on striatum ... Mus musculus Mus musculus
Gene SNCA
Cell Striatum (21 month)
Perturbation SNCA knockout
Disease PD
32 Peroxiredoxin-like peroxidase DJ-1 knockdown ... Homo sapiens Homo sapiens
Gene PARK7
Cell SHSY5Y neuroblastoma ...
Perturbation DJ1 knockdown
Disease PD
33 Parkinson's disease: substantia nigra (HG-U133B) Homo sapiens Homo sapiens
Cell Superior frontal gyrus
Perturbation Sporadic PD
Disease PD
34 Parkinson's disease: substantia nigra (HG-U133B) Homo sapiens Homo sapiens
Cell Lateral substantia nigra
Perturbation Sporadic PD
Disease PD
35 Parkinson's disease: substantia nigra (HG-U133B) Homo sapiens Homo sapiens
Cell Medial substantia nigra
Perturbation Sporadic PD
Disease PD
36 Parkinson's disease: substantia nigra Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation PD
Disease PD
37 Parkinson's disease: substantia nigra Homo sapiens Homo sapiens
Cell Substantia nigra (male)
Perturbation PD
Disease PD
38 Parkinson's disease: substantia nigra Homo sapiens Homo sapiens
Cell Substantia nigra (female)
Perturbation PD
Disease PD
39 Nurr1 overexpression effect on neural stem cells Mus musculus Mus musculus
Gene NR4A2
Cell Neural stem cells (NSCs)
Perturbation Nurr1 overexpression
Disease PD
40 Dopaminergic neurons from the substantia nigra ... Rattus norvegicus Rattus norvegicus
Cell Substantia nigra pars ...
Perturbation Normal animals
Disease PD
41 Dopamine neurons from substantia nigra pars ... Rattus norvegicus Rattus norvegicus
Cell Substantia nigra pars ...
Perturbation Normal animals
Disease PD
42 Human iPSC-derived dopaminergic neurons ... Homo sapiens Homo sapiens
Cell iPSCderived dopamine ...
Perturbation Sporadic PD
Disease PD
43 Gene expression data from induced Pluripotent ... Homo sapiens Homo sapiens
Gene GBA
Cell iPSCs
Perturbation N370S mutation in GBA ...
Disease PD
44 Role of cytochrome c in α-synuclein radical ... Mus musculus Mus musculus
Cell Nigrostriatal tissue
Perturbation Treatment with Maneb ...
Disease PD
45 Role of cytochrome c in α-synuclein radical ... Mus musculus Mus musculus
Cell Nigrostriatal tissue
Perturbation Alphasynuclein KO ...
Disease PD
46 Role of cytochrome c in α-synuclein radical ... Mus musculus Mus musculus
Cell Nigrostriatal tissue
Perturbation Alphasynuclein KO ...
Disease PD
47 Gene expression data from induced Pluripotent ... Homo sapiens Homo sapiens
Gene SNCA
Cell iPSC derived from ...
Perturbation SNCA A53T
Disease PD
48 Gene expression data from induced Pluripotent ... Homo sapiens Homo sapiens
Gene SNCA
Cell iPSC derived from ...
Perturbation SNCA triplication
Disease PD
49 Genome-wide analysis of RARβ transcriptional ... Mus musculus Mus musculus
Gene RARB
Cell Nucleus accumbens (in ...
Perturbation RARβnull mutant
Disease HD, PD, AD
50 Estradiol facilitates functional integration ... Mus musculus Mus musculus
Cell Striatum
Perturbation WGA protein injection
Disease PD
51 Expression signatures of dopaminergic neurons ... Mus musculus Mus musculus
Gene PITX3
Cell Ventral tegmental ...
Perturbation Pitx3 KO
Disease PD
52 Expression signatures of dopaminergic neurons ... Mus musculus Mus musculus
Gene PITX3
Cell Substantia nigra ...
Perturbation Pitx3 KO
Disease PD
53 Blood transcriptomics of drug-naïve sporadic ... Homo sapiens Homo sapiens
Cell Blood
Perturbation Sporadic PD
Disease PD
54 Dickkopf 3 Promotes the Differentiation of ... Mus musculus Mus musculus
Cell iPSCderived midbrain ...
Perturbation WNT1 and DKK3 treatment
Disease PD
55 Dickkopf 3 Promotes the Differentiation of ... Mus musculus Mus musculus
Cell Midbrain DA neurons ...
Perturbation Compared to ...
Disease PD
56 Dickkopf 3 Promotes the Differentiation of ... Mus musculus Mus musculus
Cell Midbrain DA neurons ...
Perturbation Compared to ...
Disease PD
57 Identification of neurexophilin 3 as a novel ... Mus musculus Mus musculus
Cell Striatum
Perturbation Acute MPTP administration
Disease PD
58 Identification of neurexophilin 3 as a novel ... Mus musculus Mus musculus
Cell Striatum
Perturbation Chronic MPTP ...
Disease PD
59 Evidence for immune response, axonal ... Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation Braak αsynuclein ...
Disease PD
60 Evidence for immune response, axonal ... Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation Braak αsynuclein ...
Disease PD
61 Evidence for immune response, axonal ... Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation Braak αsynuclein ...
Disease PD
62 Disrupted iron homeostasis causes dopaminergic ... Mus musculus Mus musculus
Gene TFRC
Cell Ventral midbrain
Perturbation Tfr1null dopaminergic ...
Disease PD
63 Disrupted iron homeostasis causes dopaminergic ... Mus musculus Mus musculus
Gene TFRC
Cell Ventral midbrain
Perturbation Tfr1null dopaminergic ...
Disease PD
64 Gene expression analysis of midbrain dopamine ... Mus musculus Mus musculus
Cell Ventral mesencephalon
Perturbation Ngn2GFP positive (E12.5)
Disease PD
65 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Dorsal nucleus of ...
Perturbation Braak stage 4
Disease PD
66 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Dorsal nucleus of ...
Perturbation Braak stage 5
Disease PD
67 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation Braak stage 4
Disease PD
68 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Substantia nigra
Perturbation Braak stage 5
Disease PD
69 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Locus coeruleus
Perturbation Braak stage 4
Disease PD
70 Transcriptional interaction network analyses ... Homo sapiens Homo sapiens
Cell Locus coeruleus
Perturbation Braak stage 5
Disease PD
71 Gene expression data from substantia nigral ... Mus musculus Mus musculus
Cell Substantia nigra
Perturbation MPTP treatment
Disease PD
72 Gene expression data from substantia nigral ... Mus musculus Mus musculus
Cell Substantia nigra
Perturbation MPTP and acupoints ...
Disease PD
73 Gene expression data from substantia nigral ... Mus musculus Mus musculus
Cell Substantia nigra
Perturbation MPTP and nonacupoints ...
Disease PD
74 Genome-wide analysis of gene expression in ... Mus musculus Mus musculus
Gene PARK7
Cell Differentiated C2C12 ...
Perturbation DJ1 siRNA
Disease PD