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| Title / Description | Chronic suppression of phosphodiesterase 10A effect on striatum and hippocampus |
| Accession | GSE40377 |
| Summary | Analysis of C57BL6 striatum and hippocampus following chronic inhibition of PDE10A activity by dosing with PDE10A inhibitor TP-10 or by PDE10A knockout. PDE10A transcripts are significantly downregulated in Huntington's disease (HD) brain. Results provide insight into the molecular basis of HD. |
| Organism | Mus musculus |
| Platform | GPL1261 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | PDE10A |
| Cell | Hippocampus (PDE10A KO) |
| Perturbation | Inhibition (PDE10i) |
| Disease | Huntington |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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