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| Title / Description | H9 hESC-derived neural stem cells harboring pathogenic leucine-rich repeat kinase 2 mutation |
| Accession | GDS4401 |
| Summary | Analysis of LRRK2 (Gly2019Ser) mutant neural stem cells (NSC) treated with LRRK2 kinase specific inhibitor LRRK2-IN-1. The LRRK2 (G2019S) mutation causes familial Parkinson's disease. Results provide insight into molecular basis of progressive degeneration of NSCs caused by pathogenic LRRK2. |
| Organism | Homo sapiens |
| Platform | GPL571 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | LRRK2 |
| Cell | Neural stem cell (NSC) |
| Perturbation | LRRK2 G2019S mutation |
| Disease | PD |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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