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| Title / Description | Parkinson's disease induced pluripotent stem cell model with triplication of the α-synuclein locus |
| Accession | GDS4156 |
| Summary | Analysis of iPSC lines derived from a PD patient with SNCA triplication and an unaffected first-degree relative. Triplication of SNCA, encoding α-synuclein, causes an aggressive form of PD. Results provide insight into the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction. |
| Organism | Homo sapiens |
| Platform | GPL570 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | SNCA |
| Cell | iPSC |
| Perturbation | SNCA triplication |
| Disease | PD |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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