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| Title / Description | Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb and paraquat-induced model of Parkinson's disease |
| Accession | GSE89562 |
| Summary | Altogether results show that peroxidase activity of cytochrome c contributes to α-synuclein radical formation and oligomerization, and that α-synuclein through its co-localization with cytochrome c or on it's own, affects several biological pathways which contribute to increased neuronal death in Maneb and paraquat (MP)-induced model of Parkinson's disease. |
| Organism | Mus musculus |
| Platform | GPL4134 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell | Nigrostriatal tissue |
| Perturbation | Treatment with Maneb and paraquat (MP) |
| Disease | PD |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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