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| Title / Description | TYK2 and STAT1 silencing effect on JURKAT T-cell acute lymphoblastic leukemia cell line |
| Accession | GSE44652 |
| Summary | Analysis of JURKAT cells transduced with TYK2 and STAT1 shRNAs. JAK tyrosine kinase TYK2 and downstream effector STAT1 promote survival of T-ALL cells. Results provide insight into the molecular mechanisms underlying TYK2-STAT1 pathway dependence in T-cell ALL. |
| Organism | Homo sapiens |
| Platform | GPL570 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | TYK2 |
| Cell | Tcell acute lymphoblastic leukemia cell line |
| Perturbation | silencing |
| Disease | leukemia |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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