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| Title / Description | Inhibitor of NEDD8-activating enzyme MLN4924 effect on melanoma cell line |
| Accession | GSE30531 |
| Summary | Analysis of A375 melanoma cells treated with small molecule MLN4924 for up to 24 hrs. MLN4924 selectively inhibits Nedd8-activating enzyme resulting in inactivation of the entire family of Cullin-RING ubiquitin ligases. Results provide insight into the molecular basis of MLN4924-induced cell death. |
| Organism | Homo sapiens |
| Platform | GPL570 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell | A375 |
| Perturbation | MLN4924 |
| Disease | 650nM - 2hr |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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