MELANOMA_PERTURBATION gene signatures (52)

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Title Organism Platform Optional Metadata
1 Oncogenic BRAF harboring melanoma cell line ... Homo sapiens Homo sapiens
Cell BRAFV600E A375
Perturbation Vemurafenib
Disease Melanoma - 10 μM
2 PGC1alpha depletion effect on melanoma cell line Homo sapiens Homo sapiens
Gene PPARGC1A
Cell A375P
Perturbation Depletion
Disease Melanoma
3 CD133 depletion effect on metastatic melanoma ... Homo sapiens Homo sapiens
Gene PROM1
Cell FEMXI
Perturbation Knockdown
Disease Melanoma
4 Dual roles of RNF2 in melanoma progression ... Homo sapiens Homo sapiens
Gene RNF2
Cell Melanocytes ...
Perturbation Over expression
Disease Melanoma
5 Shp2 transcriptome in melanoma Homo sapiens Homo sapiens
Gene PTPN11
Cell 1205Lu
Perturbation Knockdown
Disease Melanoma
6 TGFβ1 treatment of A2058 melanoma cells Homo sapiens Homo sapiens
Cell A2058
Perturbation TGFβ1
Disease Melanoma - 5ng/ml
7 siRNA induced silencing of CITED1 in HT144 ... Homo sapiens Homo sapiens
Gene CITED1
Cell HT144
Perturbation Silencing
Disease Melanoma
8 Transcriptome data from human malanoma A375 ... Homo sapiens Homo sapiens
Gene MAP4K5
Cell A375
Perturbation Knockdown
Disease Melanoma
9 Functional analysis of ABCB5 in melanoma cells Homo sapiens Homo sapiens
Gene ABCB5
Cell A375
Perturbation Knockdown
Disease Melanoma
10 Analysis of global changes in gene expression ... Homo sapiens Homo sapiens
Gene PNPT1
Cell HO1
Perturbation Knockdown
Relevant disease Melanoma
11 Synergistic anti-tumor activity by association ... Homo sapiens Homo sapiens
Cell Me13
Perturbation AZD6244
Disease Melanoma - 0.1 mM - 8hrs
12 Synergistic anti-tumor activity by association ... Homo sapiens Homo sapiens
Cell Me13
Perturbation BEZ235
Disease Melanoma - 0.1 mM - 8hrs
13 Oncogenic BRAF harboring melanoma cell line ... Homo sapiens Homo sapiens
Cell A375
Perturbation Verafumib
Disease Melanoma - 10 uM - ...
14 SOX9 overexpression in melanoma Homo sapiens Homo sapiens
Gene SOX9
Cell M010817
Perturbation Overexpression
Disease Melanoma - 48hrs
15 Synergistic anti-tumor activity by association ... Homo sapiens Homo sapiens
Cell Me13
Perturbation TRAIL (TNFrelated ...
Disease Melanoma - 25 ng/ml - ...
16 Molecular changes induced by melanoma cell ... Homo sapiens Homo sapiens
Cell DMEM
Perturbation Hypoxia
Disease Malignant melanoma - 12hr
17 Gene expression profile in melanomas from ... Mus musculus Mus musculus
Gene PDK1
Cell BrafV600E ...
Perturbation Knockout
Disease Melanoma
18 The role of SOX10 in human melanoma Homo sapiens Homo sapiens
Gene SOX10
Cell M010817
Perturbation Knockdown
Disease Melanoma - 48hrs
19 The role of SOX10 in human melanoma Homo sapiens Homo sapiens
Gene SOX10
Cell M010817
Perturbation Knockdown
Disease Melanoma - 96hrs
20 Expression data from Control, Uninfected and ... Homo sapiens Homo sapiens
Cell Primary human melanocytes
Perturbation BRAFV600E mutant
Disease Melanoma
21 EWI-2 regulates melanoma growth and lung ... Homo sapiens Homo sapiens
Gene IGSF8
Cell SKmel-28
Perturbation Knockdown
Disease Melanoma
22 Gene expression profiling of enforced HOXA1 ... Homo sapiens Homo sapiens
Gene HOXA1
Cell WM115
Perturbation Transduced with
Disease Melanoma
23 Gene expression profiling of enforced HOXA1 ... Homo sapiens Homo sapiens
Gene HOXA1
Cell SkMel30
Perturbation Transduced with
Disease Melanoma
24 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation Hypoxia (1% oxygen in ...
Disease Melanoma
25 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation Hypoxia (1% oxygen in ...
Disease Melanoma
26 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375
Perturbation GSK2118436
Disease Melanoma - 24hrs - 0.1uM
27 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375
Perturbation GSK2118436
Disease Melanoma - 24hrs - 1uM
28 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375
Perturbation GSK2118436
Disease Melanoma - 24hrs - 10uM
29 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375 16R6 (A375 ...
Perturbation GSK2118436
Disease Melanoma - 24hrs - 0.1uM
30 Gene expression profiles of Wnt-1 ... Homo sapiens Homo sapiens
Gene WNT1
Cell A375
Perturbation Overexpression
Disease Melanoma
31 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375 16R6 (A375 ...
Perturbation GSK2118436
Disease Melanoma - 24hrs - 1uM
32 Gene expression profiles of Wnt-1 ... Homo sapiens Homo sapiens
Gene WNT1
Cell M24met
Perturbation Overexpression
Disease Melanoma
33 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375 16R6 (A375 ...
Perturbation GSK2118436
Disease Melanoma - 24hrs - 10uM
34 Analysis of A375 and A375 clones that acquired ... Homo sapiens Homo sapiens
Cell A375 16R6 (A375 ...
Perturbation GSK2118436
Disease Melanoma - 24hrs - 30uM
35 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation CoCl2
Disease Melanoma - 24hrs - ...
36 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation CoCl2
Disease Melanoma - 24hrs - ...
37 Role of Apollon in human melanoma resistance ... Homo sapiens Homo sapiens
Gene BIRC6
Cell Me23682
Perturbation Silencing
Disease Melanoma - 32 hrs
38 Inhibitor of NEDD8-activating enzyme MLN4924 ... Homo sapiens Homo sapiens
Cell A375
Perturbation MLN4924
Disease 650nM - 1hr
39 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation Heatshock
Disease Melanoma (1 h at ...
40 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation Lipofectamine
Disease Melanoma - 3hrs
41 Inhibitor of NEDD8-activating enzyme MLN4924 ... Homo sapiens Homo sapiens
Cell A375
Perturbation MLN4924
Disease 650nM - 2hr
42 Expression data from mouse B16-F10 cells ... Mus musculus Mus musculus
Cell B16F10
Perturbation Benzyl alcohol
Disease Melanoma - 40 mM - 1hr
43 Inhibitor of NEDD8-activating enzyme MLN4924 ... Homo sapiens Homo sapiens
Cell A375
Perturbation MLN4924
Disease 650nM - 4hr
44 Inhibitor of NEDD8-activating enzyme MLN4924 ... Homo sapiens Homo sapiens
Cell A375
Perturbation MLN4924
Disease 650nM - 8hr
45 Inhibitor of NEDD8-activating enzyme MLN4924 ... Homo sapiens Homo sapiens
Cell A375
Perturbation MLN4924
Disease 650nM - 24hr
46 Anti-proliferative effects of continued ... Homo sapiens Homo sapiens
Cell SKMel28 BR6
Perturbation Dabrafenib
Disease Melanoma- 100nM - 24hrs
47 CD133 depletion effect on metastatic melanoma ... Homo sapiens Homo sapiens
Gene PROM1
Cell FEMXI
Perturbation Knockdown
Disease Melanoma
48 KINK-1, a novel small-molecule inhibitor of ... Homo sapiens Homo sapiens
Cell A375
Perturbation KINK1 (small-molecule ...
Disease Melanoma - 5ul - 12hrs
49 KINK-1, a novel small-molecule inhibitor of ... Homo sapiens Homo sapiens
Cell A375
Perturbation KINK1 (small-molecule ...
Disease Melanoma - 5ul - 24hrs
50 KINK-1, a novel small-molecule inhibitor of ... Homo sapiens Homo sapiens
Cell A375
Perturbation KINK1 (small-molecule ...
Disease Melanoma - 5ul - 24 hrs
51 Analysis of genes regulated by FoxD3 in ... Mus musculus Mus musculus
Gene FOXD3
Cell B16F10
Perturbation Transfected with
Disease Melanoma
52 Hs 294T Cells Treated with Elesclomol Alone or ... Homo sapiens Homo sapiens
Cell Hs 294T
Perturbation Elesclomol
Disease Melanoma 100nM - 6hrs