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| Title / Description | Bone marrow microenvironment effect on imatinib-treated chronic myeloid leukemia CD34+ cells |
| Accession | GSE43225 |
| Summary | Analysis of CML cells treated with tyrosine kinase inhibitor (TKI) imatinib and BM mesenchymal stromal cells (MSCs). Coculture with MSCs protects the CML cells from TKI-mediated cell death and depletion. Results provide insight into microenvironmental protection of CML cells from TKI treatment. |
| Organism | Homo sapiens |
| Platform | GPL6244 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Cell | Bone marrow (CD34+ cells) |
| Perturbation | Imatinib 5 uM - 96 hrs |
| Disease | Chronic myeloid leukemia |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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