My Aging Report, custom report for AGING

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Gene signatures

Signatures (29) and Custom Report Builder
Title Organism Platform
1 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
2 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
3 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
4 Young and aged skeletal muscles response to long-term vigorous endurance exercise Homo sapiens Homo sapiens
5 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
6 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
7 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
8 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
9 Caloric restriction effect on aged skeletal muscle Mus musculus Mus musculus
10 Age effect on the hippocampus Mus musculus Mus musculus
11 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
12 Age effect on hematopoietic stem cells Mus musculus Mus musculus
13 Hutchinson-Gilford progeria syndrome: fibroblast (HG-U133B) Homo sapiens Homo sapiens
14 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
15 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
16 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
17 Age effect on myoblast progenitors Mus musculus Mus musculus
18 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
19 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
20 Cardiac aging Rattus norvegicus Rattus norvegicus
21 Muscle function and aging - male (HG-U133B) Homo sapiens Homo sapiens
22 Gene expression of young and old mice Mus musculus Mus musculus
23 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
24 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
25 Expression data from young and old healthy humans, as well as HGPS patients Homo sapiens Homo sapiens
26 Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle Mus musculus Mus musculus
27 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
28 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
29 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.