Gene Signatures 1 (53), custom report for AGING_M

Categorized using metadata field cell

All reports

Gene signatures

Signatures (53) and Custom Report Builder
Title Organism Platform
1 Age effect on skeletal muscle precursor cells Mus musculus Mus musculus
2 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
3 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
4 Desmin deficiency effect on young and adult skeletal muscles Mus musculus Mus musculus
5 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
6 Aging effect on bone marrow hematopoietic stem cells Homo sapiens Homo sapiens
7 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
8 BPH/J2 model of neurogenic hypertension: hypothalamus Mus musculus Mus musculus
9 Williams-Beuren Syndrome: fibroblast cell lines Homo sapiens Homo sapiens
10 Young and aged skeletal muscles response to long-term vigorous endurance exercise Homo sapiens Homo sapiens
11 Vitamin E supplementation effect on aged heart Mus musculus Mus musculus
12 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
13 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
14 Age effect on the hippocampus Mus musculus Mus musculus
15 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
16 Age effect on hematopoietic stem cells Mus musculus Mus musculus
17 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
18 Cardiac aging Rattus norvegicus Rattus norvegicus
19 Muscle function and aging - male (HG-U133B) Homo sapiens Homo sapiens
20 Expression data from whole lateral ventricle choroid plexus tissue of young (two months old) and aged (eighteen months old) CD1 male mice. Mus musculus Mus musculus
21 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
22 Altered lipid metabolism in the aging kidney identified by three layered omic analysis Mus musculus Mus musculus
23 Effects of Aging and Anatomic Location on Gene Expression in Human Retina Homo sapiens Homo sapiens
24 Effects of Aging and Anatomic Location on Gene Expression in Human Retina Homo sapiens Homo sapiens
25 Mitochondrial gene expression decline in aging is tissue-specific and independent of mitochondrial number Mus musculus Mus musculus
26 Microarray analysis of gene expression in aging in mouse sabmandibular gland. Mus musculus Mus musculus
27 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
28 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
29 Host Age is a Systemic Regulator of Gene Expression Impacting Cancer Progression Mus musculus Mus musculus
30 Age-associated Changes in Basal NF-κB Function in Human CD4+ T Lymphocytes via Dysregulation of PI3 Kinase (dataset 5) Homo sapiens Homo sapiens
31 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
32 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
33 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
34 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
35 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
36 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
37 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
38 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
39 Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area Mus musculus Mus musculus
40 Age-mediated transcriptomic changes in adult mouse substantia nigra Mus musculus Mus musculus
41 P38 signaling underlies a cell-autonomous loss of stem cell self-renewal in aged muscle Mus musculus Mus musculus
42 Hippocampal Gene Expression in Young and Adult Mice with Memory Deficits Mus musculus Mus musculus
43 Hippocampal Gene Expression in Young and Adult Mice with Memory Deficits Mus musculus Mus musculus
44 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
45 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
46 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
47 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
48 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
49 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
50 Age effect on myoblast progenitors Mus musculus Mus musculus
51 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
52 Aging lungs and genetic background Mus musculus Mus musculus
53 Aging lungs and genetic background Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.