Brain (24), custom report for AGING_M

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Gene signatures

Signatures (24) and Custom Report Builder
Title Organism Platform
1 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
2 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
3 BPH/J2 model of neurogenic hypertension: hypothalamus Mus musculus Mus musculus
4 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
5 Age effect on the hippocampus Mus musculus Mus musculus
6 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
7 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
8 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
9 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
10 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
11 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
12 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
13 Age-mediated transcriptomic changes in adult mouse brain ventral tegmental area Mus musculus Mus musculus
14 Age-mediated transcriptomic changes in adult mouse substantia nigra Mus musculus Mus musculus
15 Hippocampal Gene Expression in Young and Adult Mice with Memory Deficits Mus musculus Mus musculus
16 Hippocampal Gene Expression in Young and Adult Mice with Memory Deficits Mus musculus Mus musculus
17 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
18 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
19 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
20 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
21 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
22 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
23 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
24 Alzheimer's Disease Dataset Homo sapiens Homo sapiens

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.