mouse_by_cel, custom report for AGING_BRAIN

Categorized using metadata field cell

All reports

Gene signatures

Signatures (40) and Custom Report Builder
Title Organism Platform
1 Age-related gene expression changes in mouse neocortex Mus musculus Mus musculus
2 Nuclear and extranuclear mutant huntingtin exon 1 protein effect on cerebellum Mus musculus Mus musculus
3 Gene expression profile of N171-HD82Q hippocampus and cerebellum. Mus musculus Mus musculus
4 Huntington's disease transgenic model: time course Mus musculus Mus musculus
5 Hippocampal gene expression changes during age-related cognitive decline Mus musculus Mus musculus
6 Hippocampal gene expression in aged and young HSD1 knockout mice Mus musculus Mus musculus
7 BPH/J2 model of neurogenic hypertension: hypothalamus Mus musculus Mus musculus
8 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
9 Age effect on the hippocampus Mus musculus Mus musculus
10 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
11 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
12 Hippocampal gene expression in aged and young HSD1 knockout mice Mus musculus Mus musculus
13 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
14 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
15 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
16 Analysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access Mus musculus Mus musculus
17 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
18 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
19 The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome Mus musculus Mus musculus
20 Altered gene expression is associated with age-dependent memory impairment Mus musculus Mus musculus
21 Coenzyme Q10-dependent gene expression in SAMP1 mice tissues Mus musculus Mus musculus
22 Hippocampal gene expression changes during age-related cognitive decline Mus musculus Mus musculus
23 Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle Mus musculus Mus musculus
24 Brain_Aging mouse mouse
25 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
26 Age effect on the hippocampus Mus musculus Mus musculus
27 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
28 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
29 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
30 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
31 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
32 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
33 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
34 Huntington disease model: brain striatum (430 2.0) Mus musculus Mus musculus
35 Spinocerebellar ataxia type 1 knock-in model: cerebellum Mus musculus Mus musculus
36 Visual cortex during the critical period for ocular dominance (MG-U74A) Mus musculus Mus musculus
37 Vitamin E supplementation effect on aged brain Mus musculus Mus musculus
38 Prefrontal cortex postnatal development: time course Mus musculus Mus musculus
39 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus
40 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.