SIRT1 gene signatures (37)

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Title Organism Platform Optional Metadata
1 SIRT1 deficiency effect on the brain Mus musculus Mus musculus
Gene SIRT1
Cell Brain
Perturbation Knockout
2 SIRT1 deficiency effect on the liver Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Knockout
3 Histone deacetylase Sirt1 overexpression ... Mus musculus Mus musculus
Gene SIRT1
Cell Heart
Perturbation Overexpression
4 Gene expression profile in Liver, skeletal ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Overexpression
5 Gene expression profile in Liver, skeletal ... Mus musculus Mus musculus
Gene SIRT1
Cell Muscle
Perturbation Overexpression
6 Gene expression profile in Liver, skeletal ... Mus musculus Mus musculus
Gene SIRT1
Cell Brown adipose tissue
Perturbation Overexpression
7 Gene expression profile in Liver, skeletal ... Mus musculus Mus musculus
Gene SIRT1
Cell Epididymal white ...
Perturbation Overexpression
8 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 500mg - 1 day
9 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 250mg - 1 day
10 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 1000mg - ...
11 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 500mg - ...
12 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 1000mg - ...
13 A Randomized, Placebo-Controlled Study to ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Skin
Perturbation SIRT1 activator, SRT2104
Disease Psoriasis - 250mg - ...
14 Gene expression profiles in Sirt1/PPARalpha ... Mus musculus Mus musculus
Gene SIRT1
Cell Heart
Perturbation Overexpression
15 Effects of Sirt1 manipulation on gene ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Caco2
Perturbation Knockdown (siRNA)
16 Effects of Sirt1 manipulation on gene ... Homo sapiens Homo sapiens
Gene SIRT1
Cell Caco2
Perturbation Overexpression
17 SRT2104 extends survival of male mice on a ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation SIRT1 activator, SRT2104
Disease Standard diet - 1.33 ...
18 SRT2104 extends survival of male mice on a ... Mus musculus Mus musculus
Gene SIRT1
Cell Muscle
Perturbation SIRT1 activator, SRT2104
Disease Standard diet - 1.33 ...
19 Histone/Protein Deacetylase-6, -9, and ... Mus musculus Mus musculus
Gene SIRT1
Cell Regulatory Tcells ...
Perturbation Conditional knockout
Disease (CD4 cre recombinase)
20 Histone/Protein Deacetylase-6, -9, and ... Mus musculus Mus musculus
Gene SIRT1
Cell Regulatory Tcells ...
Perturbation Conditional knockout
Disease (Foxp3 cre recombinase)
21 Expression analysis upon SIRT1 knockdown in ... Homo sapiens Homo sapiens
Gene SIRT1
Cell MCF7
Perturbation Knockdown
22 SRT1720 extends healthspan and lifespan in ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation SRT1720, SIRT1 Activator
Disease High-fat diet - 30mg/kg
23 SRT1720 extends healthspan and lifespan in ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation SRT1720, SIRT1 Activator
Disease High-fat diet - 100mg/kg
24 Gene expression profiles of adult neural stem ... Mus musculus Mus musculus
Gene SIRT1
Cell Secondary neurospheres
Perturbation Knockout
Disease 6 days
25 DOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 ... Mus musculus Mus musculus
Gene SIRT1
Cell MLLAF9 (Murine ...
Perturbation EPZ4777
Disease 3uM - 21 days
26 Role of SIRT1 in diet-induced metabolic diseases Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation SIRT1+/
Disease High-fat diet
27 Role of SIRT1 in diet-induced metabolic diseases Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation SIRT1+/
Disease Low-fat diet
28 SIRT1 but not its increased expression is ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Knockout (Homozygous)
Disease Caloric Restriction
29 SIRT1 but not its increased expression is ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Knockout (Heterozygous)
Disease Caloric Restriction
30 SIRT1 but not its increased expression is ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Knockout (Homozygous)
Disease Ad Lib diet
31 SIRT1 but not its increased expression is ... Mus musculus Mus musculus
Gene SIRT1
Cell Liver
Perturbation Knockout (Heterozygous)
Disease Ad Lib diet
32 SIRT1 deficiency enhances RA induced mESC ... Homo sapiens; Mus musculus Homo sapiens; Mus musculus
Gene SIRT1
Cell E14 mESC cells
Perturbation Deficiency
33 High Fat Diet Triggers SIRT1 Cleavage in ... Mus musculus Mus musculus
Gene SIRT1
Cell White adipose tissue
Perturbation Knockout
Disease Low fat diet
34 High Fat Diet Triggers SIRT1 Cleavage in ... Mus musculus Mus musculus
Gene SIRT1
Cell White adipose tissue
Perturbation Knockout
Disease High fat diet
35 Brown adipose tissue from WT and SIRT1tg mice Mus musculus Mus musculus
Gene SIRT1
Cell Brown adipose tissue
Perturbation Overexpression
36 SIRT1 deficiency in microglia contributes to ... Mus musculus Mus musculus
Gene SIRT1
Cell Microglia
Perturbation Aging
Disease Young Vs old
37 Expression data from adult NSCs/neural ... Mus musculus Mus musculus
Gene SIRT1
Cell NSCs/neural ...
Perturbation NestinCre;Sirt1lox/lox ...