Interaction network and enrichment analysis of genes downregulated in inflammatory bowel disease
Canned Analysis
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General Information
AccessionDCA00033073
TitleInteraction network and enrichment analysis of genes downregulated in inflammatory bowel disease
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by inflammatory bowel disease and healthy control cells in the Colon biopsy cell type.
Analysis URLhttp://genemania.org/#/search/human/AQP8|SLC26A2|RPL30|RPL34|NACAP1|ZG16|PRDX6|RPS10|GUCA2A|PABPC3|RPL13AP5|CKB|RPL39|RPL32|RPL41|RLIM|TXNIP|RPL3|RPS18|HNRNPA1P10|COX1|RPL6|FTH1P5|COX2|RPL36A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:551
Cell TypeColon biopsy
DO IDDOID:0050589
Disease Nameinflammatory bowel disease
Organismhuman
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM95473, GSM95474, GSM95475, GSM95476, GSM95477, GSM95478, GSM95479, GSM95480
Perturbed SamplesGSM95511, GSM95512, GSM95513, GSM95514, GSM95515, GSM95516, GSM95517, GSM95518, GSM95519, GSM95520, GSM95521, GSM95522, GSM95523, GSM95524, GSM95525
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4183
Gene Expression Omnibus
Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature
21
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