Interaction network and enrichment analysis of genes downregulated in hypertension
Canned Analysis
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General Information
AccessionDCA00033143
TitleInteraction network and enrichment analysis of genes downregulated in hypertension
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by hypertension and healthy control cells in the CNS - Brain (MMHCC) cell type.
Analysis URLhttp://genemania.org/#/search/rat/Clu|Ndrg2|Crip2|Psap|Ntsr2|Sparcl1|Ckb|Aldoc|Bsg|LOC360231|Tspan3|Atp6v0c|Itm2b|Mt3|Snrpn|Olfm1|Nrgn|Ctss|Prkar1b|Mag|Mrfap1|Dnm1|Ddn|Sirt2|Cox8a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJoel.Dudley
CREEDS IDdz:209
Cell TypeCNS - Brain (MMHCC)
DO IDDOID:10763
Disease Namehypertension
Organismrat
UMLS CUIC0020538
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM60118, GSM60119
Perturbed SamplesGSM60122, GSM60123, GSM60124
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2739
Gene Expression Omnibus
Angiotensin II type 1 receptor antagonist effect on brain microvessels of hypertensive animals
7
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