Interaction network and enrichment analysis of genes upregulated in childhood type dermatomyositis
Canned Analysis
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General Information
AccessionDCA00034280
TitleInteraction network and enrichment analysis of genes upregulated in childhood type dermatomyositis
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between cells affected by childhood type dermatomyositis and healthy control cells in the Skeletal muscle biopsies - long duration cell type.
Analysis URLhttp://genemania.org/#/search/human/HLA-A|ISG15|IFI27|HLA-C|TNNI2|HLA-B|TXNIP|ATP2A1|IFITM3|IFITM1|TCAP|CFL1|HBA2|TPM3|B2M|EEF1A1|ACTB|CASQ1|IFIT1|IFI44L|ACTG1|MX1|MLLT11|MYL3|IFITM2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdz:771
Cell TypeSkeletal muscle biopsies - long duration
DO IDDOID:14203
Disease Namechildhood type dermatomyositis
Organismhuman
UMLS CUIC0263666
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM303205, GSM303206, GSM303207, GSM303208
Perturbed SamplesGSM303190, GSM303191, GSM303192, GSM303193, GSM303194, GSM303196, GSM303197, GSM303199, GSM303200, GSM303201, GSM303203, GSM303204, GSM303209, GSM303210, GSM303211, GSM303212
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11971
Gene Expression Omnibus
Untreated juvenile dermatomyositis muscle biopsies
14
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