Interaction network and enrichment analysis of genes downregulated following Captopril treatment
Canned Analysis
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General Information
AccessionDCA00034521
TitleInteraction network and enrichment analysis of genes downregulated following Captopril treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Captopril treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/mouse/Nppa|Myl2|Tmem45b|Cox7a1|Me1|Pkm|Plin2|Tnnc1|Phlda3|Mpc1|Slc25a1|Pygl|Acat2|Tcap|Tnni3|Suclg1|LOC100048884|Actc1|Psmb7|Tecr|Retnla|Hadha|Agpat2|Acaa2|H2-K1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2689
Drug NameCaptopril
DrugBank IDDB01197
Organismmouse
PubChem CID44093
SMILES IDCC(CS)C(=O)N1CCCC1C(=O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM478606, GSM478607
Perturbed SamplesGSM478608, GSM478609
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19286
Gene Expression Omnibus
ACE inhibitor captopril effect on atherosclerosis model: aorta
14
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