Interaction network and enrichment analysis of genes downregulated following Lubiprostone treatment
Canned Analysis
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General Information
AccessionDCA00035219
TitleInteraction network and enrichment analysis of genes downregulated following Lubiprostone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Lubiprostone treated cells and untreated control cells.
Analysis URLhttp://genemania.org/#/search/mouse/Amy2a4|Gsdmc2|Cela3a|Try5|Oat|Ctrb1|Olfm4|Ces2d-ps|Lct|Cela2a|Dnase1|Cela1|Cpa1|Cpb1|S100g|Prss2|Gm3776|Reg3a|Pnlip|Gsdmc|Ckmt1|Hist1h2br|Hist1h2bc|Clps|Usmg5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2778
Drug NameLubiprostone
DrugBank IDDB01046
Organismmouse
PubChem CID656719
SMILES IDCCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM457637, GSM457639
Perturbed SamplesGSM457638, GSM457640
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE18327
Gene Expression Omnibus
Lubiprostone effect on cystic fibrosis small intestine phenotype
7
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