Interaction network and enrichment analysis of genes downregulated following 2,3-dimethoxy-1,4-naphtoquinone (dmnq) treatment
Canned Analysis
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General Information
AccessionDCA00036375
TitleInteraction network and enrichment analysis of genes downregulated following 2,3-dimethoxy-1,4-naphtoquinone (dmnq) treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3-dimethoxy-1,4-naphtoquinone (dmnq) treated cells and untreated control cells in the epithelial lung cells cell type.
Analysis URLhttp://genemania.org/#/search/human/S100A9|S100A7|SPRR1B|SLPI|CSTA|HSPB1|KRT13|SPRR1A|ID1|MT1X|HIST1H2BK|ISG15|SGK1|KRTDAP|TXNIP|FABP5|CD24|TNFSF10|SERPINB3|ITM2B|LGALS7B|ID3|NCOA4|LCN2|IFITM1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3681
Cell Typeepithelial lung cells
Drug Name2,3-dimethoxy-1,4-naphtoquinone (dmnq)
Organismhuman
PubChem CID3136
SMILES IDCOC1=C(C(=O)C2=CC=CC=C2C1=O)OC
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM980285, GSM980286, GSM980287
Perturbed SamplesGSM980288, GSM980289, GSM980290
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39843
Gene Expression Omnibus
Expression data of cystic fibrosis and non-cystic fibrosis airway cell lines under oxidative stress
14
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