Interaction network and enrichment analysis of genes upregulated in AIRE NULL MUTATION
Canned Analysis
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General Information
AccessionDCA00036658
TitleInteraction network and enrichment analysis of genes upregulated in AIRE NULL MUTATION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between AIRE NULL MUTATION cells and control cells in the Medullary epithelial cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Serpinb2|Hamp|Cd52|Fmnl2|Csn2|Ank|Tmsb4x|Calcb|Rpl34|Fnbp1l|H2-Aa|Serpinb6b|Mreg|Krt79|Ftl2|Pla1a|Bnip3|LOC100048552|5730403I07Rik|Basp1|Ftl1|Rpl32|Sepp1|Kdm1b|Dnajb9
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1172
Cell TypeMedullary epithelial cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeNULL MUTATION
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM304908, GSM304909, GSM304910
Perturbed SamplesGSM304911, GSM304912, GSM304913
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE12073
Gene Expression Omnibus
Aire ectopic expression effect on pancreatic islet beta cells
14
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