Interaction network and enrichment analysis of genes downregulated in AIRE Ectopic expression - (transgenic AIRE overexpression)
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00036659
TitleInteraction network and enrichment analysis of genes downregulated in AIRE Ectopic expression - (transgenic AIRE overexpression)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between AIRE Ectopic expression - (transgenic AIRE overexpression) cells and control cells in the Pancreatic islet beta cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ctrc|Reg3a|Ggh|Pnliprp2|Pnlip|Cuzd1|Pah|Spink3|1810028F09Rik|Gp2|Mt2|Reg2|Gm4076|Gm10334|Serpini2|Reg3d|Reg3b|Pdia2|Tmed6|Dmbt1|Serp1|Aqp12|Tff2|Ins1|Cela2a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1173
Cell TypePancreatic islet beta cells
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeEctopic expression - (transgenic AIRE overexpression)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM304902, GSM304903, GSM304904
Perturbed SamplesGSM304905, GSM304906, GSM304907
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12073
Gene Expression Omnibus
Aire ectopic expression effect on pancreatic islet beta cells
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.