Interaction network and enrichment analysis of genes downregulated in CLDN16 Deficiency
Canned Analysis
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General Information
AccessionDCA00036663
TitleInteraction network and enrichment analysis of genes downregulated in CLDN16 Deficiency
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CLDN16 Deficiency cells and control cells in the Kidneys - Homozygous null cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Akr1c18|Hbb-bs|Guca2b|Rps29|Klk1|Hba-a1|Spink3|ND4|Hbb-bt|Inmt|Rps21|Sif1|Umod|ND4L|Rpl3|Chchd1|Polr2l|Hint1|Kap|Wfdc15b|Gpx3|Mgp|Rnaset2b|Gm10029|Txnip
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1177
Cell TypeKidneys - Homozygous null
Gene Symbol (human)CLDN16
Gene Symbol (mouse)Cldn16
Organismmouse
Perturbation TypeDeficiency
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM498687, GSM498688, GSM498689, GSM498690
Perturbed SamplesGSM498694, GSM498695, GSM498696, GSM498697
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19961
Gene Expression Omnibus
Claudin16 deficiency effect on kidneys
14
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