Interaction network and enrichment analysis of genes upregulated in H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
Canned Analysis
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General Information
AccessionDCA00036742
TitleInteraction network and enrichment analysis of genes upregulated in H3F3A Mutation (G34R - mutation of key residues in histone H3.3)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between H3F3A Mutation (G34R - mutation of key residues in histone H3.3) cells and control cells in the Pediatric glioblastoma (GBM) tumors cell type.
Analysis URLhttp://genemania.org/#/search/human/CTHRC1|HBB|CSRP2|MT1E|HIST1H4C|TMSB4XP8|TMEM158|RPS26|HBA2|PMP2|OCIAD2|COX2|HMGB2|BASP1|LOC728825|PROM1|LINC00461|GPR137B|RPL27|LPL|DCAF6|DYNLT3|FAM129A|SDCBP|KPNA2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1228
Cell TypePediatric glioblastoma (GBM) tumors
Gene Symbol (human)H3F3A
Organismhuman
Perturbation TypeMutation (G34R - mutation of key residues in histone H3.3)
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM855946, GSM855948, GSM855949, GSM855950, GSM855951, GSM855952, GSM855953, GSM855954, GSM855955, GSM855956, GSM855958, GSM855959, GSM855960, GSM855961, GSM855962, GSM855963, GSM855964, GSM855965
Perturbed SamplesGSM855942, GSM855943, GSM855944
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34824
Gene Expression Omnibus
Pediatric glioblastoma brain tumors: histone H3.3 mutations
14
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