Interaction network and enrichment analysis of genes downregulated in PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
Canned Analysis
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General Information
AccessionDCA00037001
TitleInteraction network and enrichment analysis of genes downregulated in PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PIAS1 Null mutation (IFN-gamma agent treatment, 2/4 hours) cells and control cells in the mouse immune system cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rpl41|Eef1a1|Lyz1|Ctsd|Spp1|Rps16-ps2|Gm20746|Prdx1|Lgals1|H2-K2|Ccl9|Fth1|Gbp2|Tyrobp|S100a6|Tmsb4x|H2-D1|Tuba1b|Rpl28|Tmsb10|Rpl34|Rpl19|Rps23|Hmox1|Gm10260
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1379
Cell Typemouse immune system
Gene Symbol (human)PIAS1
Gene Symbol (mouse)Pias1
Organismmouse
Perturbation TypeNull mutation (IFN-gamma agent treatment, 2/4 hours)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM26693, GSM26694
Perturbed SamplesGSM26688, GSM26689
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1552
Gene Expression Omnibus
Interferon signaling in PIAS1 null mutants: time course
14
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