Interaction network and enrichment analysis of genes downregulated in ERBB3 drugactivation
Canned Analysis
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General Information
AccessionDCA00037745
TitleInteraction network and enrichment analysis of genes downregulated in ERBB3 drugactivation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ERBB3 drugactivation cells and control cells in the melanocytes cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mlana|Gpm6a|Pmel|Mme|Met|Mgll|Slc7a8|Oca2|Fstl4|Enpp2|Plxnc1|Tyrp1|Apoe|Dct|Eya1|Slc3a2|Vim|Alcam|Scpep1|Ndrg1|Slc24a5|B2m|Rab38|Sytl2|Dhrs3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1899
Cell Typemelanocytes
Gene Symbol (human)ERBB3
Gene Symbol (mouse)Erbb3
Organismmouse
Perturbation Typedrugactivation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM536238, GSM536239, GSM536240
Perturbed SamplesGSM536235, GSM536236, GSM536237
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21463
Gene Expression Omnibus
NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells
7
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