CBFA2T3 knockdown and ectopic IKKbeta(EE) expression effect on Non-Hodgkin's lymphoma Reh cells
Transcriptomics Dataset
FAIR Metrics
0 evaluations
General Information
AccessionGSE20115
TitleCBFA2T3 knockdown and ectopic IKKbeta(EE) expression effect on Non-Hodgkin's lymphoma Reh cells
DescriptionAnalysis of Reh cells following transfection with shRNA targeting CBFA2T3, constitutively active IKKbeta(EE), or both in combination. Loss of CBFA2T3 expression is linked to LTR derepression. Results provide insight into the involvement of LTR derepression in the pathogenesis of human lymphomas.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20115
RepositoryGene Expression Omnibus
Tools used to analyze the dataset
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset
Filters  
Dataset Accession
Tool Name
Direction
Cell Type
Hs Gene Symbol
Pert Type
Mm Gene Symbol
Geneset
Small molecules which mimic IKBKB transient expression of constitutively active IKKβ(E
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse IKBKB transient expression of constitutively active IKKβ(E
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic CBFA2T3 KD
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse CBFA2T3 KD
L1000CDS2, Characteristic Direction
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated in IKBKB transient expression of constitutively active IKKβ(E
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated in CBFA2T3 KD
PAEA, Characteristic Direction
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated in IKBKB transient expression of constitutively active IKKβ(E
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in IKBKB transient expression of constitutively active IKKβ(E
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes downregulated in CBFA2T3 KD
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
Interaction network and enrichment analysis of genes upregulated in CBFA2T3 KD
GeneMANIA, Characteristic Direction
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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