PGC1alpha depletion effect on melanoma cell line
Transcriptomics Dataset
FAIR Metrics
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General Information
AccessionGSE36879
TitlePGC1alpha depletion effect on melanoma cell line
DescriptionAnalysis of A375P melanoma cells depleted for PGC1alpha. PGC1alpha is a transcriptional coactivator that promotes mitochondrial biogenesis and respiration. A375P is a cell line that overexpresses PGC1alpha. Results provide insight into the role of PGC1alpha in melanoma.
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE36879
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Pert Type
Geneset

Small molecules which mimic PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse PPARGC1A KD
The L1000 database was queried in order to identify small molecule perturbations which rev...
...
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