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| Title / Description | Fibroblast-derived induced pluripotent stem cells harboring pathogenic leucine-rich repeat kinase 2 mutation |
| Accession | GDS4400 |
| Summary | Analysis of IPSCs generated from LRRK2 (Gly2019Ser) mutation-bearing patient fibroblasts by cell reprogramming. The LRRK2 (G2019S) mutation causes familial Parkinson's disease (PD). Results provide insight into the molecular mechanisms underlying PD. |
| Organism | Homo sapiens |
| Platform | GPL571 |
| Normalized | False |
| Parsed SOFT file |
| Differential expression method | Characteristic Direction |
| Cutoff | 500 |
| Gene | LRRK2 |
| Cell | WT ESC, mutant iPSC |
| Perturbation | LRRK2 G2019S mutation (heterozygous) |
| Disease | PD |
| Principal Component Analysis | |
| Hierarchical clustering |
| Gene lists | Enrichr | L1000CDS2 | PAEA | |
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