AGING_PHILLIP report

Categorized using metadata field Cell

All reports

Gene signatures

Signatures (87) and Custom Report Builder
Title Organism Platform
1 Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle Mus musculus Mus musculus
2 Age effect on skeletal muscle precursor cells Mus musculus Mus musculus
3 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
4 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
5 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
6 Premature Hematopoietic Aging model: bone marrow hematopoietic stem cells Mus musculus Mus musculus
7 Aging effect on bone marrow hematopoietic stem cells Homo sapiens Homo sapiens
8 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
9 Induced pluripotent stem cell-based accelerated aging model Homo sapiens Homo sapiens
10 Caloric restriction effect on the aged heart and adipose tissue Rattus norvegicus Rattus norvegicus
11 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
12 Aging lungs and genetic background Mus musculus Mus musculus
13 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
14 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
15 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
16 Age effect on hematopoietic stem cells Mus musculus Mus musculus
17 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
18 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
19 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
20 Age effect on myoblast progenitors Mus musculus Mus musculus
21 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
22 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
23 Cardiac aging Rattus norvegicus Rattus norvegicus
24 Muscle function and aging - male (HG-U133B) Homo sapiens Homo sapiens
25 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
26 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
27 Altered lipid metabolism in the aging kidney identified by three layered omic analysis Mus musculus Mus musculus
28 Gene expression of young and old mice Mus musculus Mus musculus
29 Mitochondrial gene expression decline in aging is tissue-specific and independent of mitochondrial number Mus musculus Mus musculus
30 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
31 Effects of Aging and Anatomic Location on Gene Expression in Human Retina Homo sapiens Homo sapiens
32 Expression data from aging study on mouse spermatogonial stem/progenitor cell population Mus musculus Mus musculus
33 Expression data from aging study on mouse spermatogonial stem/progenitor cell population Mus musculus Mus musculus
34 Microarray analysis of gene expression in aging in mouse sabmandibular gland. Mus musculus Mus musculus
35 SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta Mus musculus Mus musculus
36 SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1beta Mus musculus Mus musculus
37 Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions Mus musculus Mus musculus
38 Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions Mus musculus Mus musculus
39 Aging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression) Homo sapiens Homo sapiens
40 REST and Stress Resistance in Aging and Alzheimer’s Disease Homo sapiens Homo sapiens
41 Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice. Mus musculus Mus musculus
42 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
43 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
44 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
45 Epigenetic determinants of muscle stem cell quiescence and chronological aging Mus musculus Mus musculus
46 Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging Homo sapiens Homo sapiens
47 An Epigenetic Component of Hematopoietic Stem Cell Aging Amenable to Reprogramming Into a Young State Mus musculus Mus musculus
48 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
49 Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Mus musculus Mus musculus
50 A systems approach identifies progeroid Ercc1[-/Δ] mice as a model system for kidney aging. Mus musculus Mus musculus
51 Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice Mus musculus Mus musculus
52 Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice Mus musculus Mus musculus
53 Analysis of the gene expression within the cochlea of aging C57BL6j mice. Mus musculus Mus musculus
54 Aging effect on bone marrow hematopoietic stem cells Homo sapiens Homo sapiens
55 The impact of aging on memory T cell phenotype and function in the human bone marrow Homo sapiens Homo sapiens
56 Premature Hematopoietic Aging model: bone marrow hematopoietic stem cells Mus musculus Mus musculus
57 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
58 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
59 Hepatic gene expression changes in aging and R-α-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms. Rattus norvegicus Rattus norvegicus
60 The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome Mus musculus Mus musculus
61 Distinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases Mus musculus Mus musculus
62 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
63 Aging of Human Fibroblast Homo sapiens Homo sapiens
64 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
65 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
66 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
67 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
68 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
69 Alzheimer's Disease Dataset Homo sapiens Homo sapiens
70 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
71 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
72 Resistance Exercise Reverses Aging in Human Skeletal Muscle Homo sapiens Homo sapiens
73 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
74 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
75 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
76 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
77 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
78 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
79 Transcriptional profile of aging human muscle Homo sapiens Homo sapiens
80 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
81 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
82 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
83 Aging Liver Profiles of the Long Lived Prop-1 Mutant Mouse (Ames) and Wild Type Controls Mus musculus Mus musculus
84 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
85 Age effect on myoblast progenitors Mus musculus Mus musculus
86 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
87 Cardiac aging Rattus norvegicus Rattus norvegicus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.