Kinase Enrichment Analysis version 3Kinase Enrichment Analysis 3 (KEA3) infers upstream kinases whose putative substrates are overrepresented in a user-inputted list of proteins or differentially phosphorylated proteins.
Download libraries
"Primary" libraries are used by KEA3 to conduct kinase enrichment analysis. "Benchmarking" libraries were used to benchmark KEA3. "Additional" libraries are available as an additional resource to the community. "Primary" and "Additional" libraries were generated to only include kinases with four or more interactions, and all gene symbols are HGNC-approved.
| Library type and name |
Unique Kinases | Unique Substrates | Mean Set Size | Download | |
|---|---|---|---|---|---|
| Primary | |||||
| BioGRID | 240 | 2,251 | 24 |
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| Cheng.KSIN | 227 | 2,154 | 31 |
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| HIPPIE | 474 | 8,798 | 97 |
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| Mentha | 474 | 8,639 | 72 |
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| MINT | 156 | 1,383 | 72 |
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| Cheng.PPI | 376 | 4,678 | 40 |
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| PTMsigDB | 163 | 2,262 | 32 |
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| STRING | 514 | 18,213 | 1,235 |
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| STRING.bind | 432 | 5,254 | 72 |
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| PhosD.All | 339 | 6,544 | 368 |
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| PrePPI | 519 | 14,382 | 658 |
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| The Kinase Library | 392 | 9,122 | 627 |
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| Benchmarking | |||||
| PTMsigDB.drug | - | - | - |
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| KinCREEDSupdn | - | - | - |
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| DrugL1000updn | - | - | - |
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| Additional | |||||
| PSOPIA | 44 | 493 | 14 |
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| PhosphoSitePlus | 165 | 2,269 | 32 |
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| PhosphoNetworks.rawKSI | 285 | 1,914 | 83 |
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| PhosphoNetworks.comKSI | 181 | 1,115 | 23 |
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| PhosphoNetworks.refKSI | 164 | 717 | 21 |
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| PhosD.ELM | 161 | 3,799 | 127 |
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| PhosD.PSP | 212 | 5,565 | 246 |
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| ARCHS4.coexp | 515 | 16,711 | 300 |
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| GTEx.coexp | 515 | 17,769 | 300 |
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| PIPs | 266 | 2,068 | 50 |
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| REACTOME | 178 | 1,209 | 22 |
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| Phospho.ELM | 39 | 418 | 16 |
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| Hu.MAP | 33 | 294 | 12 |
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