Hepatic gene expression in streptozotocin-induced diabetic mice fed a quercetin diet
Transcriptomics Dataset
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General Information
AccessionGSE38067
TitleHepatic gene expression in streptozotocin-induced diabetic mice fed a quercetin diet
DescriptionQuercetin is a food component that may ameliorate the diabetic symptoms. We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)-induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes-associated liver injury. We fed STZ-induced diabetic mice with diets containing 0.1%% or 0.5%% quercetin for 2 weeks and compared the patterns of hepatic gene expression in these groups of mice using a DNA microarray. Diets containing 0.1%% or 0.5%% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5%% quercetin diet suppressed STZ-induced alteration of gene expression. Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had their greatest suppressive effect on the STZ-induced elevation of expression of cyclin dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a).
Landing Pagehttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38067
RepositoryGene Expression Omnibus
Tools used to analyze the dataset

Keyword
Dataset Accession

Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
PAEA
Published November 2015
Enrichment analysis tool implementing the principal angle method
3879
Canned Analyses generated with the dataset

Dataset Accession
Tool Name
Direction
Cell Type
Drug Name
Geneset

Small molecules which mimic Streptozocin treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Streptozocin treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic Quercetin treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Quercetin treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Small molecules which mimic Quercetin treatment
The L1000 database was queried in order to identify small molecule perturbations which mim...
Small molecules which reverse Quercetin treatment
The L1000 database was queried in order to identify small molecule perturbations which rev...
Enrichment analysis of genes dysregulated following Streptozocin treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated following Quercetin treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Enrichment analysis of genes dysregulated following Quercetin treatment
An enrichment analysis was performed on the top most dyresgulated genes determined by appl...
Interaction network and enrichment analysis of genes downregulated following Streptozocin treatment
The analysis explores the gene interaction network and pathway enrichment of the top 50 mo...
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