Brain, custom report for AG

All reports

Gene signatures

Signatures (73) and Custom Report Builder
Title Organism Platform
1 Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle Mus musculus Mus musculus
2 Age-related gene expression changes in mouse neocortex Mus musculus Mus musculus
3 Gene expression profiling in differential cognitive outcomes in aging: CA3 Rattus norvegicus Rattus norvegicus
4 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
5 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
6 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
7 Age effect on the hippocampus Mus musculus Mus musculus
8 Hippocampal gene expression in aged and young HSD1 knockout mice Mus musculus Mus musculus
9 Hippocampal gene expression changes during age-related cognitive decline Mus musculus Mus musculus
10 Huntington disease model: brain striatum (430 2.0) Mus musculus Mus musculus
11 Huntington's disease transgenic model: time course Mus musculus Mus musculus
12 Huntington's disease transgenic model: time course Mus musculus Mus musculus
13 Gene expression profile of N171-HD82Q hippocampus and cerebellum. Mus musculus Mus musculus
14 Expression data from 9 and 13 weeks old TIFIAD1Cre mice Mus musculus Mus musculus
15 Striatal gene expression data from 3- and 18-month-old Q92 mice and control mice. Mus musculus Mus musculus
16 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
17 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
18 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
19 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
20 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
21 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
22 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
23 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
24 REST and Stress Resistance in Aging and Alzheimer’s Disease Homo sapiens Homo sapiens
25 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
26 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
27 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
28 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
29 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
30 BPH/J2 model of neurogenic hypertension: hypothalamus Mus musculus Mus musculus
31 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
32 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
33 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
34 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
35 Analysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access Mus musculus Mus musculus
36 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
37 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
38 The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome Mus musculus Mus musculus
39 Altered gene expression is associated with age-dependent memory impairment Mus musculus Mus musculus
40 Brain_Aging mouse mouse
41 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
42 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
43 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
44 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
45 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
46 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
47 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
48 Schizophrenia: postmortem anterior prefrontal cortex Homo sapiens Homo sapiens
49 Schizophrenia: postmortem superior temporal cortex Homo sapiens Homo sapiens
50 Spinocerebellar ataxia type 1 knock-in model: cerebellum Mus musculus Mus musculus
51 Visual cortex during the critical period for ocular dominance (MG-U74A) Mus musculus Mus musculus
52 Prefrontal cortex postnatal development: time course Mus musculus Mus musculus
53 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus
54 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus
55 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
56 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
57 Vitamin E supplementation effect on aged brain Mus musculus Mus musculus
58 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
59 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
60 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
61 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
62 Coenzyme Q10-dependent gene expression in SAMP1 mice tissues Mus musculus Mus musculus
63 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
64 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
65 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
66 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
67 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
68 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
69 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
70 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
71 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
72 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
73 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.