cell, custom report for AG

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Gene signatures

Signatures (182) and Custom Report Builder
Title Organism Platform
1 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
2 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
3 Age effect on laryngeal muscle Rattus norvegicus Rattus norvegicus
4 Caloric restriction effect on the aged heart and adipose tissue Rattus norvegicus Rattus norvegicus
5 Caloric restriction effect on the aged heart and adipose tissue Rattus norvegicus Rattus norvegicus
6 Desmin deficiency effect on young and adult skeletal muscles Mus musculus Mus musculus
7 Mdr2 knockout model of hepatocellular carcinoma at precancerous stages Mus musculus Mus musculus
8 Age-related changes in gene expression in retinal microglia Mus musculus Mus musculus
9 Age-related changes in gene expression in retinal microglia Mus musculus Mus musculus
10 Age-related changes in gene expression in retinal microglia Mus musculus Mus musculus
11 Streptozotocin-induced diabetic model with acute myocardial infarction: time course Rattus norvegicus Rattus norvegicus
12 Analysis of the gene expression within the cochlea of aging C57BL6j mice. Mus musculus Mus musculus
13 Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice Mus musculus Mus musculus
14 Analysis of the gene expression within the cochlea of aging C57BL6j mice. Mus musculus Mus musculus
15 Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice Mus musculus Mus musculus
16 Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors Homo sapiens Homo sapiens
17 P38 signaling underlies a cell-autonomous loss of stem cell self-renewal in aged muscle Mus musculus Mus musculus
18 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
19 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
20 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
21 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
22 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
23 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
24 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
25 Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344 Rattus norvegicus Rattus norvegicus
26 Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle Mus musculus Mus musculus
27 Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle Mus musculus Mus musculus
28 Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle Mus musculus Mus musculus
29 Neural retina leucine zipper deficiency effect on retinas: time course Mus musculus Mus musculus
30 Neural retina leucine zipper deficiency effect on retinas: time course Mus musculus Mus musculus
31 Age-related gene expression changes in mouse neocortex Mus musculus Mus musculus
32 Effect of age on the arthritis susceptibility of BALB/c mice Mus musculus Mus musculus
33 Effect of age on the arthritis susceptibility of BALB/c mice Mus musculus Mus musculus
34 Gene expression profiling in differential cognitive outcomes in aging: CA3 Rattus norvegicus Rattus norvegicus
35 Aging of Human Fibroblast Homo sapiens Homo sapiens
36 Aging of Human Fibroblast Homo sapiens Homo sapiens
37 Age-related para-inflammation in the neuroretina of the mouse Mus musculus Mus musculus
38 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
39 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
40 Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG Rattus norvegicus Rattus norvegicus
41 Expression data from mouse bone marrow adipocytes with age Mus musculus Mus musculus
42 Expression data from mouse bone marrow adipocytes with age Mus musculus Mus musculus
43 Expression data from mouse bone marrow adipocytes with age Mus musculus Mus musculus
44 Expression data from mouse bone marrow adipocytes with age Mus musculus Mus musculus
45 Age effect on the hippocampus Mus musculus Mus musculus
46 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
47 Muscle function and aging - male (HG-U133B) Homo sapiens Homo sapiens
48 Gene expression of young and old mice Mus musculus Mus musculus
49 Expression data from young and old healthy humans, as well as HGPS patients Homo sapiens Homo sapiens
50 Age effect on myoblast progenitors Mus musculus Mus musculus
51 Hepatic gene expression changes in aging and R-α-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms. Rattus norvegicus Rattus norvegicus
52 Age-dependent decline in lung regeneration with loss of clonogenicity and myofibroblastic differentiation of lung fibroblasts Mus musculus Mus musculus
53 Hippocampal gene expression in aged and young HSD1 knockout mice Mus musculus Mus musculus
54 Hippocampal gene expression changes during age-related cognitive decline Mus musculus Mus musculus
55 Amyotrophic lateral sclerosis model Mus musculus Mus musculus
56 Amyotrophic lateral sclerosis model Mus musculus Mus musculus
57 Huntington disease model: brain striatum (430 2.0) Mus musculus Mus musculus
58 Huntington's disease transgenic model: time course Mus musculus Mus musculus
59 Huntington's disease transgenic model: time course Mus musculus Mus musculus
60 Gene expression profile of N171-HD82Q hippocampus and cerebellum. Mus musculus Mus musculus
61 Expression data from 9 and 13 weeks old TIFIAD1Cre mice Mus musculus Mus musculus
62 Moderate stage Huntington's disease lymphocytes Homo sapiens Homo sapiens
63 Striatal gene expression data from 3- and 18-month-old Q92 mice and control mice. Mus musculus Mus musculus
64 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
65 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
66 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
67 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
68 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
69 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
70 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
71 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
72 Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth Mus musculus Mus musculus
73 Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle Mus musculus Mus musculus
74 Age effect on livers of long-lived Snell dwarf mutants Mus musculus Mus musculus
75 Muscle function and aging - female (HG-U133B) Homo sapiens Homo sapiens
76 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
77 The effects of aging on circadian patterns of gene expression in the human prefrontal cortex Homo sapiens Homo sapiens
78 Mitochondrial gene expression decline in aging is tissue-specific and independent of mitochondrial number Mus musculus Mus musculus
79 Effects of Aging and Anatomic Location on Gene Expression in Human Retina Homo sapiens Homo sapiens
80 Expression data from aging study on mouse spermatogonial stem/progenitor cell population Mus musculus Mus musculus
81 Microarray analysis of gene expression in aging in mouse sabmandibular gland. Mus musculus Mus musculus
82 Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions Mus musculus Mus musculus
83 Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions Mus musculus Mus musculus
84 Aging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (Expression) Homo sapiens Homo sapiens
85 REST and Stress Resistance in Aging and Alzheimer’s Disease Homo sapiens Homo sapiens
86 Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging mice. Mus musculus Mus musculus
87 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
88 Epigenetic determinants of muscle stem cell quiescence and chronological aging Mus musculus Mus musculus
89 Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging Homo sapiens Homo sapiens
90 Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Mus musculus Mus musculus
91 A systems approach identifies progeroid Ercc1[-/Δ] mice as a model system for kidney aging. Mus musculus Mus musculus
92 Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice Mus musculus Mus musculus
93 Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice Mus musculus Mus musculus
94 The impact of aging on memory T cell phenotype and function in the human bone marrow Homo sapiens Homo sapiens
95 Premature Hematopoietic Aging model: bone marrow hematopoietic stem cells Mus musculus Mus musculus
96 Distinct signature of altered homeostasis in aging rod photoreceptors: Implications for retinal diseases Mus musculus Mus musculus
97 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
98 Effect of BDNF on aging-related gene expression changes in young and aged rats Rattus norvegicus Rattus norvegicus
99 Resistance Exercise Reverses Aging in Human Skeletal Muscle Homo sapiens Homo sapiens
100 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
101 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
102 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
103 Transcriptional profile of aging human muscle Homo sapiens Homo sapiens
104 Age effect on skeletal muscle precursor cells Mus musculus Mus musculus
105 Desmin deficiency effect on young and adult skeletal muscles Mus musculus Mus musculus
106 Aging effect on bone marrow hematopoietic stem cells Homo sapiens Homo sapiens
107 Williams-Beuren Syndrome: fibroblast cell lines Homo sapiens Homo sapiens
108 Expression data from whole lateral ventricle choroid plexus tissue of young (two months old) and aged (eighteen months old) CD1 male mice. Mus musculus Mus musculus
109 Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus Rattus norvegicus Rattus norvegicus
110 Altered lipid metabolism in the aging kidney identified by three layered omic analysis Mus musculus Mus musculus
111 Aging lungs and genetic background Mus musculus Mus musculus
112 Aging lungs and genetic background Mus musculus Mus musculus
113 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
114 Age effect on normal adult brain: frontal cortical region Homo sapiens Homo sapiens
115 BPH/J2 model of neurogenic hypertension: hypothalamus Mus musculus Mus musculus
116 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
117 Alpha-synuclein deficiency effect on striatum and cerebellum: time course Mus musculus Mus musculus
118 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
119 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
120 Analysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access Mus musculus Mus musculus
121 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
122 Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area Mus musculus Mus musculus
123 The effects of aging vs. alpha7 nAChR subunit deficiency on the mouse brain transcriptome Mus musculus Mus musculus
124 Altered gene expression is associated with age-dependent memory impairment Mus musculus Mus musculus
125 Brain_Aging mouse mouse
126 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
127 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
128 Neurological aging models: retinas and hippocampi Mus musculus Mus musculus
129 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
130 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
131 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
132 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
133 Schizophrenia: postmortem anterior prefrontal cortex Homo sapiens Homo sapiens
134 Schizophrenia: postmortem superior temporal cortex Homo sapiens Homo sapiens
135 Spinocerebellar ataxia type 1 knock-in model: cerebellum Mus musculus Mus musculus
136 Visual cortex during the critical period for ocular dominance (MG-U74A) Mus musculus Mus musculus
137 Prefrontal cortex postnatal development: time course Mus musculus Mus musculus
138 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus
139 CAG repeat knock-in model of spinocerebellar ataxia type 1 progression Mus musculus Mus musculus
140 Age effect on lipopolysaccharide-induced neuroinflammation and sickness behavior Mus musculus Mus musculus
141 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
142 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
143 Age effect on extraocular muscles Rattus norvegicus Rattus norvegicus
144 Fisher 344 rat model of aging: parietal cortex Rattus norvegicus Rattus norvegicus
145 Cardiac aging Rattus norvegicus Rattus norvegicus
146 Vitamin E supplementation effect on aged heart Mus musculus Mus musculus
147 Vitamin E supplementation effect on aged brain Mus musculus Mus musculus
148 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
149 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
150 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
151 Hippocampal aging and cognitive impairment Rattus norvegicus Rattus norvegicus
152 Age-related aortic vasculopathy model Rattus norvegicus Rattus norvegicus
153 Desmin deficiency effect on young and adult skeletal muscles Mus musculus Mus musculus
154 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
155 Skeletal muscles from men and women of various ages Homo sapiens Homo sapiens
156 Young and aged skeletal muscles response to long-term vigorous endurance exercise Homo sapiens Homo sapiens
157 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
158 Model of cerebral aging and Alzheimer's disease: temporal cortex Homo sapiens; Microcebus murinus Homo sapiens; Microcebus murinus
159 Caloric restriction effect on aged skeletal muscle Mus musculus Mus musculus
160 Aging lungs and genetic background Mus musculus Mus musculus
161 An Epigenetic Component of Hematopoietic Stem Cell Aging Amenable to Reprogramming Into a Young State Mus musculus Mus musculus
162 Transcriptome analysis of aging muscle progenitors (human myoblasts) Homo sapiens Homo sapiens
163 Coenzyme Q10-dependent gene expression in SAMP1 mice tissues Mus musculus Mus musculus
164 Coenzyme Q10-dependent gene expression in SAMP1 mice tissues Mus musculus Mus musculus
165 Coenzyme Q10-dependent gene expression in SAMP1 mice tissues Mus musculus Mus musculus
166 Expression data from aging study on mouse spermatogonial stem/progenitor cell population Mus musculus Mus musculus
167 Expression data from aging study on mouse spermatogonial stem/progenitor cell population Mus musculus Mus musculus
168 Progranulin deficiency effect on various brain regions: time course Mus musculus Mus musculus
169 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
170 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
171 Rapamycin extends life span, but has limited effects on aging in mice Mus musculus Mus musculus
172 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
173 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
174 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
175 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
176 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
177 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
178 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
179 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
180 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
181 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus
182 Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration Mus musculus Mus musculus

PCA

Interactive 3D principal component analysis of gene signatures. You can rotate the visualization and mouse over the data points.

Genes

Hierarchical clustering of genes based on weights from the differential expression method.

Enrichr

Enrichr is a web tool that performs gene set enrichment analysis. To generate the hierarchical clusterings below, GEN3VA enriched each gene signature using Enrichr and then clustered the terms. Use the select button to change Enrichr's background library.

Hierarchical clustering of enriched terms from

L1000CDS2

L1000CDS2 is a web tool that queries the LINCS L1000 dataset to identify small molecules that can reverse or mimic the observed input expression pattern. To generate the hierarchical clustering below, GEN3VA enriched each gene signature using L1000CDS2 to generate a list of perturbations that either mimic (red) and reverse (blue) expression.