A2M Gene


Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

A2ML1-AS1 Gene

A2ML1 antisense RNA 1

A2MP1 Gene

alpha-2-macroglobulin pseudogene 1

A2M-AS1 Gene

A2M antisense RNA 1 (head to head)

A2ML1 Gene

alpha-2-macroglobulin-like 1

This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]