Harmonizome 3.0

skin secretory protein xP2-like

peptidase inhibitor 3, skin-derived

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

skin secretory protein xP2-like

Tuberculin skin test reactivity QTL

Tuberculin skin test reactivity, absence of

skin secretory protein xP2-like

Skin/hair/eye pigmentation 8, freckling

keratolytic winter erythema (Oudtshoorn skin disease)

skin secretory protein xP2-like

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene 1

ash1 (absent, small, or homeotic)-like (Drosophila)

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

absent in melanoma 1-like

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Mar 2025]

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

absent in melanoma 1

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Mar 2025]

absent in melanoma 2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

ash2 (absent, small, or homeotic)-like (Drosophila)

Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Involved in positive regulation of cell population proliferation; response to estrogen; and transcription initiation-coupled chromatin remodeling. Acts upstream of or within DNA damage response. Located in nucleus. Part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Mar 2025]