Harmonizome 3.0

deoxyuridine triphosphatase

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

deoxyuridine triphosphatase pseudogene 2

deoxyuridine triphosphatase pseudogene 3

deoxyuridine triphosphatase pseudogene 1

deoxyuridine triphosphatase pseudogene 6

deoxyuridine triphosphatase pseudogene 7

deoxyuridine triphosphatase pseudogene 4

deoxyuridine triphosphatase pseudogene 5

deoxyuridine triphosphatase pseudogene 8

putative deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323

Predicted to enable dUTP diphosphatase activity and magnesium ion binding activity. Predicted to be involved in dUMP biosynthetic process and dUTP catabolic process. [provided by Alliance of Genome Resources, Mar 2025]

deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like