Harmonizome 3.0

EWS RNA-binding protein 1

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

EWS RNA-binding protein 1 pseudogene

EWS RNA-binding protein 1 pseudogene

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the EWS-FLI1-20517297-SK-N-MC-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets 2022

target genes of the EWS-FLI1-20517297-SK-N-MC-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ews in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9531837-pone.0269077.s012.xlsx-EWS-FLI1_ratio_5_p_value_0_05-Gene_name_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9531837-pone.0269077.s012.xlsx-EWS-ERG_ratio_5_p_value_0_05-Gene_name_ERG transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9531837-pone.0269077.s012.xlsx-EWS-ETV4_ratio_5_p_value_0_05-Gene_name_ETV4 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B-Genes_containing_RING1B_EWSR1-FLI1_enhancers_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7608835-aba3058_Table_S4.xlsx-EWS-FLI1_RING1B_SEnh-Genes_containing_RING1B_EWSR1-FLI1_superenhancers_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_2-Gene_Symbol_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_1_vs_Type_3-Gene_Symbol_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7415402-oncotarget-11-2995-s004.xlsx-EWS-FLI1_Type_2_vs_Type_3-Gene_Symbol_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3799442-supp_gkt678_nar-01667-h-2013-File013.xlsx-ST1-EWS-FLI1_modulated_probesets_and_selected_by_GO_terms_cell_cycle_and_apoptosis_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Table_S6_Overlap_of_differentially_expressed_genes_in_Tg_HSP_EWS-FLI1_embryos_and_human_EWS-FLI1_signature_from_Smith_et_al_2006_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_1_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_3_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3255547-supp_007401_DMM007401TableS6.xls-EWS-FLI1_signatures-Unnamed_4_FLI1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.