Harmonizome 3.0

scaffolding protein involved in DNA repair

Involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation ong>ofong> double-strand break repair. Located in nuclear chromosome and nucleoplasm. Implicated in 46 XX gonadal dysgenesis. [provided by Alliance ong>ofong> Genome Resources, Mar 2025]

cellular repressor ong>ofong> E1A-stimulated genes 1

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control ong>ofong> cell growth and differentiation. [provided by RefSeq, Jul 2008]

cellular repressor ong>ofong> E1A-stimulated genes 2

Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Predicted to be active in extracellular space. [provided by Alliance ong>ofong> Genome Resources, Mar 2025]

MIR142 host genes

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part ong>ofong> RISC complex. [provided by Alliance ong>ofong> Genome Resources, Mar 2025]