Harmonizome 3.0

eyes shut homolog (Drosophila)

The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene 1

ash1 (absent, small, or homeotic)-like (Drosophila)

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

absent in melanoma 1-like

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Mar 2025]

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

ash2 (absent, small, or homeotic)-like (Drosophila) pseudogene

absent in melanoma 1

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Mar 2025]

absent in melanoma 2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

ash2 (absent, small, or homeotic)-like (Drosophila)

Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Involved in positive regulation of cell population proliferation; response to estrogen; and transcription initiation-coupled chromatin remodeling. Acts upstream of or within DNA damage response. Located in nucleus. Part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Mar 2025]