Harmonizome 3.0

lethal giant larvae homolog 2 (Drosophila)

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

lethal giant larvae homolog 1 (Drosophila)

This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Aneurysm, intracranial berry, 11

Aneurysm, intracranial berry, 10

Aneurysm, intracranial berry, 9

Aneurysm, intracranial berry, 8

Aneurysm, intracranial berry, 5

aneurysm, intracranial berry 4

Aneurysm, intracranial berry, 7

Aneurysm, intracranial berry, 6

aneurysm, intracranial berry 1

aneurysm, intracranial berry 3

aneurysm, intracranial berry 2