Harmonizome 3.0

mitochondrial ribosomal protein L27

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

ribosomal protein L27 pseudogene 12

ribosomal protein L27 pseudogene 11

ribosomal protein L27 pseudogene 10

ribosomal protein L27 pseudogene 1

ribosomal protein L27 pseudogene 2

ribosomal protein L27 pseudogene

ribosomal protein L27 pseudogene 4

ribosomal protein L27 pseudogene 5

ribosomal protein L27 pseudogene 6

ribosomal protein L27 pseudogene 7

ribosomal protein L27 pseudogene 8

ribosomal protein L27 pseudogene 9

ribosomal protein L27

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]