Harmonizome 3.0

mortality factor 4 (pseudogene)

Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]

mortality factor 4 like 2 pseudogene 1

mortality factor 4 like 1 pseudogene 1

mortality factor 4 like 1 pseudogene 2

mortality factor 4 like 1 pseudogene 3

mortality factor 4 like 1 pseudogene 4

mortality factor 4 like 1 pseudogene 5

mortality factor 4 like 1 pseudogene 6

mortality factor 4 like 1 pseudogene 7

mortality factor 4 like 2

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus; nucleoplasm; and plasma membrane. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Mar 2025]

mortality factor 4 like 1

Predicted to enable chromatin binding activity. Involved in double-strand break repair via homologous recombination; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex; Sin3-type complex; and nucleosome. [provided by Alliance of Genome Resources, Mar 2025]